AT389872B - Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen - Google Patents
Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen Download PDFInfo
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- AT389872B AT389872B AT0036984A AT36984A AT389872B AT 389872 B AT389872 B AT 389872B AT 0036984 A AT0036984 A AT 0036984A AT 36984 A AT36984 A AT 36984A AT 389872 B AT389872 B AT 389872B
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- Prior art keywords
- general formula
- compound
- reaction
- formula
- phenyl
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- -1 N-phenylpiperazino group Chemical group 0.000 claims description 23
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
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- 230000001624 sedative effect Effects 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU83414A HU188250B (en) | 1983-02-08 | 1983-02-08 | Process for producing of basical oxim-ethers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA36984A ATA36984A (de) | 1989-07-15 |
| AT389872B true AT389872B (de) | 1990-02-12 |
Family
ID=10949510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0036984A AT389872B (de) | 1983-02-08 | 1984-02-06 | Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4727074A (en]) |
| JP (1) | JPS59172454A (en]) |
| AT (1) | AT389872B (en]) |
| AU (1) | AU562028B2 (en]) |
| BE (1) | BE898835A (en]) |
| CA (1) | CA1247103A (en]) |
| CH (1) | CH660004A5 (en]) |
| DE (1) | DE3404481A1 (en]) |
| DK (1) | DK160299C (en]) |
| ES (2) | ES8606258A1 (en]) |
| FI (1) | FI78682C (en]) |
| FR (1) | FR2540493B1 (en]) |
| GB (1) | GB2134904B (en]) |
| GR (1) | GR81458B (en]) |
| HU (1) | HU188250B (en]) |
| IL (1) | IL70885A (en]) |
| NL (1) | NL8400376A (en]) |
| PH (1) | PH20863A (en]) |
| PL (1) | PL141942B1 (en]) |
| SE (1) | SE465675B (en]) |
| SU (1) | SU1353774A1 (en]) |
| YU (1) | YU21984A (en]) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU197205B (en) * | 1984-07-10 | 1989-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of medical compositions against angine |
| DE3620166A1 (de) * | 1986-06-14 | 1987-12-17 | Bayer Ag | Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern |
| HU202195B (en) * | 1987-12-31 | 1991-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing new substituted styrene derivatives and medical compositions comprising such compounds |
| HUT67314A (en) * | 1993-04-09 | 1995-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them |
| UA65635C2 (uk) * | 1998-09-03 | 2004-04-15 | Н-Гене Кутато Кфт. | НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2609017B2 (de) * | 1976-01-27 | 1980-10-09 | Egyt Gyogyszervegyeszeti Gyar, Budapest | Basische Oximäther, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3025238A1 (de) * | 1979-07-03 | 1981-03-26 | Egyt Gyógyszervegyészeti Gyár, Budapest | Basische cycloalkanonoximaether, verfahren zur herstellung derselben und diese enthaltende arzneimittel |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU169298B (en]) * | 1974-09-24 | 1976-11-28 | ||
| US4083978A (en) * | 1976-01-27 | 1978-04-11 | Egyt Gyogyszervegyeszeti Gyar | Oxime ethers |
-
1983
- 1983-02-08 HU HU83414A patent/HU188250B/hu not_active IP Right Cessation
-
1984
- 1984-02-03 BE BE1/010952A patent/BE898835A/fr not_active IP Right Cessation
- 1984-02-03 PH PH30201A patent/PH20863A/en unknown
- 1984-02-06 CH CH546/84A patent/CH660004A5/de not_active IP Right Cessation
- 1984-02-06 AT AT0036984A patent/AT389872B/de not_active IP Right Cessation
- 1984-02-07 FI FI840500A patent/FI78682C/fi not_active IP Right Cessation
- 1984-02-07 AU AU24248/84A patent/AU562028B2/en not_active Ceased
- 1984-02-07 IL IL70885A patent/IL70885A/xx unknown
- 1984-02-07 YU YU00219/84A patent/YU21984A/xx unknown
- 1984-02-07 GB GB08403233A patent/GB2134904B/en not_active Expired
- 1984-02-07 SE SE8400629A patent/SE465675B/sv not_active IP Right Cessation
- 1984-02-07 PL PL1984246099A patent/PL141942B1/pl unknown
- 1984-02-07 FR FR8401833A patent/FR2540493B1/fr not_active Expired
- 1984-02-07 CA CA000446931A patent/CA1247103A/en not_active Expired
- 1984-02-07 NL NL8400376A patent/NL8400376A/nl not_active Application Discontinuation
- 1984-02-07 DK DK054684A patent/DK160299C/da not_active IP Right Cessation
- 1984-02-08 SU SU843702235A patent/SU1353774A1/ru active
- 1984-02-08 DE DE19843404481 patent/DE3404481A1/de not_active Withdrawn
- 1984-02-08 JP JP59021513A patent/JPS59172454A/ja active Pending
- 1984-02-08 ES ES529565A patent/ES8606258A1/es not_active Expired
- 1984-02-08 US US06/578,286 patent/US4727074A/en not_active Expired - Fee Related
- 1984-02-08 GR GR73746A patent/GR81458B/el unknown
-
1985
- 1985-06-17 ES ES544287A patent/ES8604122A1/es not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2609017B2 (de) * | 1976-01-27 | 1980-10-09 | Egyt Gyogyszervegyeszeti Gyar, Budapest | Basische Oximäther, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3025238A1 (de) * | 1979-07-03 | 1981-03-26 | Egyt Gyógyszervegyészeti Gyár, Budapest | Basische cycloalkanonoximaether, verfahren zur herstellung derselben und diese enthaltende arzneimittel |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee | ||
| ELJ | Ceased due to non-payment of the annual fee |